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a-scoping-review-of-traditional-and-artificial-intelligence-methods-in-malaria-diagnostics-–-npj-digital-medicine

A scoping review of traditional and artificial intelligence methods in malaria diagnostics – npj Digital Medicine

  • Article
  • Open access
  • Published:
  • Fangxu Xing1 na1,
  • Shahar Lazarev2 na1 &
  • Jonghye Woo1 

npj Digital Medicine (2026) Cite this article

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Abstract

Malaria remains a substantial global health burden with current diagnostics having notable limitations. Microscopy is labor-intensive and operator-dependent; rapid diagnostic tests lack sensitivity and provide qualitative rather than quantitative results. Recent AI advances, particularly deep learning, demonstrate significant potential for malaria diagnostics through automatic parasite detection in blood smears. Numerous systems achieve outstanding accuracy—comparable to human experts—while increasing throughput and reducing costs. In endemic regions, AI-based diagnostics can expand testing access; in non-endemic settings, they assist clinicians rarely encountering malaria, potentially reducing misdiagnosis rates. Successful AI applications emphasize digital medicine’s broader potential to address global health disparities through automated, expert-quality diagnostics. Yet, challenges remain—inconsistent dataset annotation standards and limited representation of diverse endemic regions—for widespread AI-based diagnostic adoption. This review examines current diagnostic methods and evaluates the translational potential of AI-driven innovations in malaria diagnostics, discussing practical implications for researchers and stakeholders seeking to integrate these advances into clinical practice.

Acknowledgements

This work was supported by a research contract with Noul Inc. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Author notes

  1. These authors contributed equally: Fangxu Xing, Shahar Lazarev.

Authors and Affiliations

  1. MGB Center for Inflammation Imaging, Department of Radiology, Harvard Medical School and Mass General Brigham, Boston, MA, USA

    Fangxu Xing & Jonghye Woo

  2. Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel

    Shahar Lazarev

Authors

  1. Fangxu Xing
  2. Shahar Lazarev
  3. Jonghye Woo

Corresponding author

Correspondence to Jonghye Woo.

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Competing interests

J.W. serves as a member of the Scientific Advisory Board for Noul Inc. The remaining authors declare no competing interests. J.W. is an Editorial Board Member of npj Digital Medicine and was not involved in the journal’s review of, or decisions related to, this manuscript.

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Cite this article

Xing, F., Lazarev, S. & Woo, J. A scoping review of traditional and artificial intelligence methods in malaria diagnostics. npj Digit. Med. (2026). https://doi.org/10.1038/s41746-026-02880-3

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  • DOI: https://doi.org/10.1038/s41746-026-02880-3

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